iloperidone increases amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone can be a time-dependent CYP3A inhibitor and will bring on greater plasma levels of medicines predominantly eliminated by CYP3A4.

Other variables that are available in consist of affected person dimension, how reactive They're on the drug, and how frequently they’re taking it.

itraconazole will boost the amount or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

modafinil will enhance the degree or outcome of mavacamten by impacting hepatic enzyme CYP2C19 metabolism. Contraindicated. Strong or moderate CYP2C19 inhibitors may possibly increase mavacamten systemic publicity, resulting in heart failure as a consequence of systolic dysfunction.

apalutamide will lessen the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which can be CYP3A4 substrates may result in decreased exposure to those prescription drugs.

Indicated to enhance wakefulness in adults with too much sleepiness connected to obstructive rest apnea (OSA)

anastrozole will boost the degree or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.

Modafinil may perhaps minimize serum concentrations of other medicine into a clinically considerable extent, including the subsequent:

The usefulness of steroidal contraceptives could be decreased when utilized with PROVIGIL and for 1 month after discontinuation of therapy. Alternative or concomitant ways of contraception are proposed more information for individuals using steroidal contraceptives (e.

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It is crucial to inform your medical doctor when you grow to be Expecting. Your health care provider may want you to affix a pregnancy registry for individuals taking this drugs.

Contraindicated (two)modafinil will enhance the level or influence of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindicated. Sturdy or average CYP2C19 inhibitors could maximize mavacamten systemic exposure, leading to coronary heart failure as a result of systolic dysfunction.

It isn't recognized whether or not modafinil passes into breast milk or if it could harm a nursing baby. Convey to your doctor Should you be breast-feeding a little one.